Maternal Epilepsy and Umbilical Cord Blood Oxidative Stress Level


Yakut K., Öcal F. D. , Sanhal C., Öcal Ö., Oğuz Y., EREL Ö. , ...More

Fetal and Pediatric Pathology, 2021 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1080/15513815.2021.1957046
  • Title of Journal : Fetal and Pediatric Pathology
  • Keywords: albumin, Epilepsy, ischemia modified albumin, oxidative stress, thiol-disulfide homeostasis

Abstract

© 2021 Taylor & Francis Group, LLC.Introduction: We investigated the effect of epilepsy on cord blood oxidative stress status. Material and Methods: Thirty (n = 30) pregnant women with epilepsy and thirty (n = 30) healthy controls enrolled in this case control study. Albumin and IMA values and dynamic thiol/disulfide parameters were measured. Results: Decreased native thiol and total thiol levels were found in the epilepsy group when compared to the control group (p: 0.001, p: 0.002). Higher IMA (p: 0.036) and lower albumin cord levels (P < 0.001) were measured in the epilepsy group with respect to the control group. Apgar scores at 1 and 5 miutes were lower in the epilepsy group (respectively; p = 0.012, p = 0.010). A negative correlation was found between IMA and cord pH value (r = 0.288 p = 0.034). Conclusion: This study showed that epilepsy may alter thiol disulfide homeostasis and IMA levels.