Impact of Gestational Diabetes Mellitus and Maternal Obesity on Cord Blood Dynamic Thiol/Disulfide Homeostasis

Ozler S., Oztas E., EREL Ö., Guler B. G. , Ergin M., Uygur D., et al.

FETAL AND PEDIATRIC PATHOLOGY, cilt.36, ss.8-15, 2017 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 36 Konu: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/15513815.2016.1223237
  • Sayfa Sayısı: ss.8-15


Aim: Our aim in this study was to investigate the effect of maternal obesity and gestational diabetes mellitus (GDM) on cord blood dynamic thiol/disulfide homeostasis. Methods: A prospective case-control study was carried out in 125 pregnant women (27 GDM, 30 obese, 68 controls). Cord blood samples were collected from all participants and native thiol-disulfide exchanges were examined with automated method enabling the measurement of both sides of thiol-disulfide balance. Results: Disulfide amounts, disulfide/native thiol and disulfide/total thiol ratios were increased (p < 0.001), while native thiol/total thiol was decreased in the cord blood of babies born to an obese or diabetic mother (p < 0.001). Moreover, increased disulfide amounts, disulfide/native thiol, disulfide/totalthiol ratios and decreased native/total thiol were found to be significantly associated with adverse outcomes in GDM. Conclusion: The current study suggests that the offsprings born to obese or diabetic mothers are exposed to increased oxidative stress.