Vitamin C ameliorates high dose Dexmedetomidine induced liver injury

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ARSLAN M., Sezen S., Turgut H., Kocabiyik M., Arpaci H., Comu F., ...Daha Fazla

Bratislava Medical Journal, cilt.117, sa.1, ss.36-40, 2016 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4149/bll_2016_008
  • Dergi Adı: Bratislava Medical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.36-40
  • Anahtar Kelimeler: Dexmedetomidine, Liver histopathology, MDA, Rat, SOD, Vitamin C
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet

Özet

BACKGROUND: We investigated whether vitamin C has protective effects on rat liver tissue treated with different dexmedetomidine doses. MATERIAL AND METHODS: Thirty fi ve wistar albino rats were randomly divided into 5 groups (Control (0.9 % NaCl intraperitoneally (ip), Dexmedetomidine 5 μg.kg-1 (ip), Dexmedetomidine 5 μg.kg-1 ip plus Vitamin C (100 mg.kg-1), Dexmedetomidine 10 μg.kg-1 ip and Dexmedetomidine 10 μg.kg-1 ip plus Vitamin C (100 mg.kg-1). Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated. RESULTS: Hepatocyte degeneration was signifi cantly higher in D10 group than those in other study groups (p < 0.0001, p = 0.002, p < 0.0001, p = 0.005, respectively). Similarly, liver tissue sinusoidal dilatation and hepatocyte necrosis were signifi cantly higher in D10 group than those in other groups (p < 0.0001, p < 0.0001, p = 0.002, p < 0.0001 and p < 0.0001, p = 0.046, p < 0.0001 and p = 0.002, respectively). Tissue MDA levels in D10 group were signifi cantly higher than those in control, D5+Vit C and D10+Vit C groups (p = 0.028, p = 0.004, p = 0.031, respectively). SOD enzyme activity in D10 group was signifi cantly lower than in control, D5+Vit C and D10+Vit C groups (p < 0.0001, p = 0.023 and p = 0.031, respectively). CONCLUSION: High dose dexmedetomidine can induce hepatic injury and oxidative stress in rats while pretreatment with vitamin C may be effective in protecting liver tissue against this newly recognized undesirable dexmedetomidine effect.