Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss
Journal of Laryngology and Otology, vol.130, no.5, pp.447-452, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 130 Issue: 5
- Publication Date: 2016
- Doi Number: 10.1017/s002221511600092x
- Journal Name: Journal of Laryngology and Otology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.447-452
- Keywords: Disulfides, Hearing Loss, Sudden, Oxidative Stress, Reactive Oxygen Species, Thiols
- Ankara Yıldırım Beyazıt University Affiliated: Yes
Abstract
Objectives: To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time. Methods: Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects. Results: Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls (p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002). Conclusion: The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.