IGF-I and IGFBP-3 levels and their correlations with carcinoembryonic antigen in colorectal cancer patients

Yucel C. Y., Erden G., YILMAZ F. M., Sezer S., Calci E.

ALEXANDRIA JOURNAL OF MEDICINE, vol.54, no.1, pp.11-15, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1016/j.ajme.2017.02.001
  • Journal Name: ALEXANDRIA JOURNAL OF MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.11-15
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Background: Colorectal cancer is one of the most frequently seen cancers worldwide. Currently, CEA is the most commonly used tumor marker in colorectal cancer. The changes in IGF/IGFBP equilibrium is also known to cause carcinogenesis. In this study, we aimed to monitor IGF-I/IGFBP-3 levels, the changes in IGF-I/IGFBP-3 ratio and correlations of these peptides with the common tumor marker CEA.