Prospective comparison of two treatment modalities in benign prostate hyperplasia: Alpha-blocker alone vs. alpha-blocker plus anticholinergic combination Benign prostat hiperplazisi olgularında i̇ki tedavi modalitesinin prospektif karşılaştırılması: Tek başına alfa bloker ile alfa bloker ve antikolinerjik kombinasyon tedavisi

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Aldemir M., Aǧras K., Dehni D., Kayigil Ö.

Turkiye Klinikleri Journal of Medical Sciences, vol.30, no.2, pp.539-543, 2010 (SCI-Expanded, Scopus)

Abstract

Objective: We investigated the efficiency and reliability of treatments with alfuzosin alone and in combination with tolterodine in patients with benign prostate hyperplasia accompanied by lower urinary system symptoms. Material and Methods: Forty-five males, ages over forty that applied to the clinic between April 2007 and July 2007 were included in the evaluation. As the initial examinations, international prostate symptom score, peak floq rate in uroflowmentry and post-voiding measurement of the residual urine were performed. Treatment of the patients who were included in the study was started with 10 mg alfuzosin (Group 1). At the end of the third month, tolterodine 2 mg taken twice a day was added to the treatment (Group 2). Results: Thirty-seven patients (82%) out of 45 patients were able to complete the six-month study. Average age of these patients was 59.2 ± 7.2 years. The average prostate specific antigen value of the patients was found as 1.4 ± 1.0 (ng/mL), and the average prostate volume as 34.8 ± 13.1 ml. Four patients left the study after tolterodine was added because of intensive dryness in the mouth. According to the statistical data, at the end of the study, significant improvement was found in both groups when compared to baseline. Conclusion: When the two treatments were compared, no statistical differences were noted between the two groups. © 2010 by Türkiye Klinikleri.