CD81 Expression in the Differential Diagnosis of Chronic Lymphocytic Leukemia

Afacan-Öztürk H. B. , Falay M., Albayrak M., Yıldız A., Öztürk Ҫ. P. , Maral S., ...More

Clinical laboratory, vol.65, no.3, 2019 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.7754/clin.lab.2018.180802
  • Journal Name: Clinical laboratory
  • Journal Indexes: Science Citation Index Expanded, Scopus


BACKGROUND: Immunophenotyping has a central role in CLL. However, CLL is a very heterogenous disease, both morphologically and immunophenotypically; thus, its diagnosis may prove a challenge. We investigated CD81 ex-pression in the differential diagnosis of CLL and MCL. METHODS: We retrospectively examined CD81 expression with 8 color Multiparameter Flow cytometry devices in 101 CLL and 19 MCL cases. RESULTS: We found negative CD81 expression in CLL cases whereas it was positive in MCL cases. CONCLUSIONS: Our results suggest that CD81 may be a valuable marker for the differential diagnosis of CLL. We are of the opinion that it should be definitely included in the diagnostic algorithm for CLL.