Research Information System
Turk Kardiyoloji Dernegi Arsivi, vol.22, no.6, 1994 (Scopus)
In 36 patients with cyanotic heart disease the effects of aprotinin on the coagulation mechanism were studied as well as the amount of drainage blood and homologous blood usage during and after open heart surgery. Of these patients, while 18 served as a control group, in the remaining 18 patients aprotinin was used. Total blood loss was 560 ± 125 mL/m2 in the control group and 287 mL/m2 in the aprotinin group (p < 0.001). In the control group 18 units of homologous blood was used in the aprotinin group. The bleeding time in the control group was longer than in the aprotinin group at the postoperative 90th minute. α-2 antiplasmin activity in the aprotinin group was significantly increased (p < 0.001). Plasminogen activity decreased at the first and 12th postoperative hours. Platelet factor 4 and β-thromboglobulin serving as an index of platelet activity were reduced in the aprotinin group (p < 0.05). The other hematologic tests did not show a significant difference. In conclusion, antifibrinolytic and platelet-protective effects of aprotinin seemed to reduce the postoperative drainage blood and homologous blood requirement.