Antibody false positivity among covid-19 convalescent plasma donors: A comparative study from the turkish red crescent blood center
Haseki Tip Bulteni, cilt.59, sa.5, ss.353-357, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 5
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/haseki.galenos.2021.7383
- Dergi Adı: Haseki Tip Bulteni
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.353-357
- Anahtar Kelimeler: False HIV, convalescent plasma, serologic tests, immunoassay
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
© 2021 by The Medical Bulletin of İstanbul Haseki Training and Research Hospital The Medical Bulletin of Haseki published by Galenos Yayınevi.Aim: During our routine work at the Turkish Red Crescent (TRC) laboratories, human deficiency virus (HIV) 1/2 antibody false-positive results were observed among Coronavirus disease-2019 convalescent plasma (CP) donors more frequently than healthy donors. We aimed to determine anti-HIV 1/2 antibody false-positivity rates among the CP donors and healthy blood donors. Methods: The present study was designed as a cross-sectional study which was a type of observational study. Total 3689 donations from 2593 donors donated CP to the TRC between 11 April-06 July 2020, were screened by electrochemiluminescence immunoassay for the presence of antibody against HIV ½. The confirmation tests were performed with line immunoassay. All of the donors were non-remunerated CP donors between the ages of 18-60. For the control group, 411078 donations from 407363 healthy blood donors were received on the same days. Results: Repeated reactivity rates (1.87%) were significantly higher than the control group (0.13%, p<0.05). However, there was not a statistically significant difference between the confirmed reactivity rates of the study group (0.03%) and the control group (0.01%, p=0.217). Conclusion: In our study, it was determined that the false-positive results obtained from serologic HIV screening tests of CP donors were significantly higher when compared to the healthy blood donors.