Effects of Recurrent Sevoflurane Anesthesia on Erythrocyte Deformability in Experimentally Induced Alzheimer Rats Deneysel Alzheimer Oluşturulmuş Yaşlı Ratlarda Tekrarlayan Sevofluran Anestezisinin Eritrosit Deformabilitesi Üzerine Etkisinin Değerlendirilmesi
Gazi Medical Journal, cilt.33, sa.1, ss.25-28, 2022 (Scopus)
- Yayın Türü: Makale / Özet
- Cilt numarası: 33 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.12996/gmj.2022.06
- Dergi Adı: Gazi Medical Journal
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier
- Sayfa Sayıları: ss.25-28
- Anahtar Kelimeler: Alzheimer disease, Animal models experimental, Erythrocyte deformability, Rat, Sevoflurane
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objectives: The aim of this study was to investigate the association between Alzheimer's disease and erythrocyte deformability and to assess whether recurrent sevoflurane anesthesia influenced this association. Methods: A total of 24 Wistar albino rats were divided into four groups: Control, sevoflurane, Alzheimer, and Alzheimer + sevoflurane. The experimental Alzheimer model was prepared by intracerebroventricular injection of streptozotocin at a dose of 3 mg/kg (10 μl) to the Alzheimer and Alzheimer + sevoflurane groups. Sevoflurane (2.3%) was administered to the sevoflurane and Alzheimer + sevoflurane groups 4 weeks after the surgery for 3 days and lasting for 2 hours per day. Blood samples were then collected for deformability measurements. Results: The deformability index was significantly increased in Alzheimer-induced rats, but the results for the Alzheimer and Alzheimer + sevoflurane groups were similar. The erythrocyte deformability index was significantly increased in the Alzheimer and Alzheimer + sevoflurane groups (p=0.004 p=0.001 respectively). However, there was no difference in deformability in the sevoflurane group (p= 0.496) Conclusion: Erythrocyte deformability was increased in the Alzheimer-induced rats; however recurrent sevoflurane anesthesia did not affect erythrocyte deformability.