TNF-α and IL-6 as biomarkers of impaired lung functions in dimethylacetamide exposure
Journal of Medical Biochemistry, cilt.38, sa.3, ss.276-283, 2019 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.2478/jomb-2018-0040
- Dergi Adı: Journal of Medical Biochemistry
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.276-283
- Anahtar Kelimeler: dimethylacetamide (DMAc), interleukin-6 (IL-6), pulmonary capacities, toxic inhalation, tumour necrosis factor-α (TNF-α)
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
© 2019 Lütfiye Tutkun, Servet Birgin Iritaş, Serdar Deniz, Özgür Öztan, Sedat Abuşoǧlu, Ali Ünlü, Vugar Ali Türksoy, Sultan Plnar Çetintepe.Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc exposed people. 101 non-exposed control subjects (Group 1) and 109 DMAc-exposed workers from the polyvinyl chloride (PVC) industry were included in the study. In the next step, the exposed group was divided into two groups according to the level of exposure (Group 2 and 3). DMAc, TNF-α, IL-6, creatinine, ALT, AST, GFR and standard spirometry measurements were carried out in all subjects. When compared to the control group, TNF-α and IL-6 levels were significantly high compatible with the increase of DMAc levels, in the exposed groups. Urinary DMAc Levels were 0.06 mg/L in the control group. This level is significantly low when compared to exposed and severely exposed group (2.43 mg/L and 3.17 mg/L). TNF-α levels were 56.86 pg/mL, 145.52 pg/mL and 230.52 pg/mL in control, exposed and severely exposed groups. IL-6 levels were found to be 38.08 pg/mL, 89.19 pg/mL and 116 pg/mL for control, exposed and severely exposed groups, respectively. Similarly, the FEV1/FVC ratio decreased especially in the severely exposed group (p 0.001). In our study, results have revealed that TNF-and IL-6 levels are promising biomarkers in the early diagnosis of lung function impairment in inhalational DMAc exposure.