An evaluation of maternal serum dynamic thioldisulfide homeostasis and ischemia modified albumin changes in pregnant women with COVID-19 COVID-19 olan gebe kadınlarda maternal serum dinamik tiyoldisülfit dengesinin ve iskemi modifiye albümin değişikliklerinin değerlendirilmesi

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Erol S. A. , Anuk A. T. , Tanaçan A., Semiz H., Keskin H. L. , NEŞELİOĞLU S. , ...More

Turkish Journal of Obstetrics and Gynecology, vol.19, no.1, pp.21-27, 2022 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.4274/tjod.galenos.2022.72929
  • Title of Journal : Turkish Journal of Obstetrics and Gynecology
  • Page Numbers: pp.21-27
  • Keywords: COVID-19, Ischemia-modified albumin, Pregnancy outcomes, Thiol-disulfide homeostasis


© 2022 by Turkish Society of bstetrics and Gynecology.Objective: It is thought that oxidative stress, free radicals, reactive oxygen species and reactive nitrogen species affect the pathophysiology of coronavirus disease-2019 (COVID-19). This study aimed to evaluate the oxidative status in pregnant patients with COVID-19 infection according to the changes seen in the levels of maternal serum thiol-disulfide and ischemia-modified albumin (IMA). Materials and Methods: A study group was formed of 40 pregnant women with confirmed COVID-19 infection (study group) and a control group of 40 healthy pregnant women with no risk factors determined. In this prospective, case-controlled study, analyses were made of the maternal serum native thiol, total thiol, disulfide, IMA, and disulfide/native thiol concentrations. Results: The maternal serum native thiol and total thiol concentrations in the study group were determined to be statistically significantly lower (p=0.007 and p=0.006, respectively), and the disulfide/native thiol ratio was higher but not to a level of statistical significance (p=0.473). There was no difference between the two groups regarding IMA levels (p=0.731). Conclusion: The thiol-disulfide balance was seen to shift in the oxidant direction in pregnancies with COVID-19, which might support the view that ischemic processes play a role in the etiopathogenesis of this novel disease.