An evaluation of maternal serum dynamic thioldisulfide homeostasis and ischemia modified albumin changes in pregnant women with COVID-19 COVID-19 olan gebe kadınlarda maternal serum dinamik tiyoldisülfit dengesinin ve iskemi modifiye albümin değişikliklerinin değerlendirilmesi

Creative Commons License

Erol S. A., Anuk A. T., Tanaçan A., Semiz H., Keskin H. L., NEŞELİOĞLU S., ...More

Turkish Journal of Obstetrics and Gynecology, vol.19, no.1, pp.21-27, 2022 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.4274/tjod.galenos.2022.72929
  • Journal Name: Turkish Journal of Obstetrics and Gynecology
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM), Scopus
  • Page Numbers: pp.21-27
  • Keywords: COVID-19, ischemia-modified albumin, pregnancy outcomes, thiol-disulfide homeostasis
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

© 2022 by Turkish Society of bstetrics and Gynecology.Objective: It is thought that oxidative stress, free radicals, reactive oxygen species and reactive nitrogen species affect the pathophysiology of coronavirus disease-2019 (COVID-19). This study aimed to evaluate the oxidative status in pregnant patients with COVID-19 infection according to the changes seen in the levels of maternal serum thiol-disulfide and ischemia-modified albumin (IMA). Materials and Methods: A study group was formed of 40 pregnant women with confirmed COVID-19 infection (study group) and a control group of 40 healthy pregnant women with no risk factors determined. In this prospective, case-controlled study, analyses were made of the maternal serum native thiol, total thiol, disulfide, IMA, and disulfide/native thiol concentrations. Results: The maternal serum native thiol and total thiol concentrations in the study group were determined to be statistically significantly lower (p=0.007 and p=0.006, respectively), and the disulfide/native thiol ratio was higher but not to a level of statistical significance (p=0.473). There was no difference between the two groups regarding IMA levels (p=0.731). Conclusion: The thiol-disulfide balance was seen to shift in the oxidant direction in pregnancies with COVID-19, which might support the view that ischemic processes play a role in the etiopathogenesis of this novel disease.