Thiol/disulfide homeostasis and its relationship with insulin resistance in patients with rosacea

Demir Pektas S., Cinar N., Pektas G., Akbaba G., Kara A., Hancer H. S. , ...More

Journal of Cosmetic Dermatology, 2021 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.1111/jocd.14477
  • Title of Journal : Journal of Cosmetic Dermatology
  • Keywords: insulin resistance, metabolic disorder, oxidative stress, rosacea, thiol/disulfide homeostasis


© 2021 Wiley Periodicals LLC.Background: Rosacea is a chronic inflammatory cutaneous disease that can be associated with cardiometabolic disorders. Oxidative stress is included in the pathogenesis of rosacea, and thiol-disulfide homeostasis (TDH) acts as antioxidants. Objective: To evaluate the TDH and metabolic parameters in patients with rosacea. Material and Methods: A total of 42 rosacea patients and 50 controls participated in this prospective study. Demographic data, clinical entities, anthropometric measurements, and laboratory findings were recorded. Additionally, TDH was measured by an automated spectrophotometric method. Results: Rosacea patients had greater body mass index values (27.9 ± 5.2 kg/m² vs. 23 ± 1.4 kg/m², p < 0.001), waist-hip ratios (0.87 ± 0.1 vs. 0.77 ± 0.8, p < 0.001), and insulin resistance (3.0 ± 2.0 vs. 1.3 ± 0.5, p < 0.001) compared with controls. Disulfide levels, the disulfide/native thiol ratio (DNTR), and the disulfide/total thiol ratio (DTTR) were increased (p < 0.05) in rosacea patients. Native thiol and total thiol levels and the native/total thiol ratio (NTTR) were decreased in rosacea patients (p < 0.05). Different rosacea subtypes had no effect on oxidative stress markers. The duration of illness and insulin resistance values significantly correlated with DNTR and DTTR in the rosacea group (p < 0.05). Conclusion: Rosacea has a metabolic milieu with increased oxidative stress and insulin resistance.