A current and comprehensive review of cyclin-dependent kinase inhibitors for the treatment of metastatic breast cancer


Bilgin B., Sendur M. A. N. , Dede D. S. , Akinci M. B. , Yalcin B.

CURRENT MEDICAL RESEARCH AND OPINION, vol.33, no.9, pp.1559-1569, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 33 Issue: 9
  • Publication Date: 2017
  • Doi Number: 10.1080/03007995.2017.1348344
  • Title of Journal : CURRENT MEDICAL RESEARCH AND OPINION
  • Page Numbers: pp.1559-1569

Abstract

Background: Resistance to endocrine treatment generally occurs over time, especially in the metastatic stage. In this paper, we aimed to review the mechanisms of cyclin-dependent kinase (CDK) 4/6 inhibition and clinical usage of new agents in the light of recent literature updates.