Direct antiglobulin test positivity in children with acute lymphoblastic leukemia at diagnosis

Gokcebay D. G., Kara A., Ok Bozkaya I., Culha V., Yarali N., Tunc B., ...More

Pediatric Hematology and Oncology, vol.32, no.7, pp.490-494, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 7
  • Publication Date: 2015
  • Doi Number: 10.3109/08880018.2015.1076915
  • Journal Name: Pediatric Hematology and Oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.490-494
  • Keywords: ALL, children, Coombs test, direct antiglobulin test
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


© 2015 Taylor & Francis Group, LLC.Direct antiglobulin test positivity had been reported in the course of some lymphoproliferative neoplasms. However, there are a few case reports describing direct antiglobulin test (DAT) positivity in children with acute lymphoblastic leukemia (ALL). We herein report 8 patients who had positive DAT among 95 newly diagnosed children with ALL. None of these patients had evidence of hemolysis during the follow-up. An antibody was detected in 2 of 8 patients with positive DAT. These 2 children also had positive indirect antiglobulin test (IAT); an autoantibody that was reactive at 4°C, and an alloantibody (anti E) that was reactive at 37°C was detected. We believe DAT positivity in ALL without significant hemolysis is not a rare disorder, and a need for further prospective studies is apparent.