Direct antiglobulin test positivity in children with acute lymphoblastic leukemia at diagnosis


Gokcebay D. G. , Kara A., Ok Bozkaya I., Culha V., Yarali N. , Tunc B., ...More

Pediatric Hematology and Oncology, vol.32, no.7, pp.490-494, 2015 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 7
  • Publication Date: 2015
  • Doi Number: 10.3109/08880018.2015.1076915
  • Title of Journal : Pediatric Hematology and Oncology
  • Page Numbers: pp.490-494
  • Keywords: ALL, children, Coombs test, direct antiglobulin test

Abstract

© 2015 Taylor & Francis Group, LLC.Direct antiglobulin test positivity had been reported in the course of some lymphoproliferative neoplasms. However, there are a few case reports describing direct antiglobulin test (DAT) positivity in children with acute lymphoblastic leukemia (ALL). We herein report 8 patients who had positive DAT among 95 newly diagnosed children with ALL. None of these patients had evidence of hemolysis during the follow-up. An antibody was detected in 2 of 8 patients with positive DAT. These 2 children also had positive indirect antiglobulin test (IAT); an autoantibody that was reactive at 4°C, and an alloantibody (anti E) that was reactive at 37°C was detected. We believe DAT positivity in ALL without significant hemolysis is not a rare disorder, and a need for further prospective studies is apparent.