JARCHO-LEVIN SYNDROME PRESENTING WITH SEVERE HYDROCEPHALUS: A REPORT OF THREE CASES


Yurttutan S., Degirmencioglu H., Oncel M. Y. , Kara S., Sari F., Dilmen U.

GENETIC COUNSELING, cilt.24, ss.361-366, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 24 Konu: 4
  • Basım Tarihi: 2013
  • Dergi Adı: GENETIC COUNSELING
  • Sayfa Sayıları: ss.361-366

Özet

Jarcho-Levin syndrome presenting with severe hydrocephalus: a report of three cases: Jarcho-Levin syndrome (JLS) is a genetic disorder characterized by defects of spine formation, abnormal fusion of the ribs at the costovertebral and costochondral junction due to abnormal vertebral and costal segmentation. There are two subtypes associated with different distribution and severity of defects in JLS. While vertebral segmentation abnormalities are frequent in spondylo-thoracic subtype costal segmentation and fusion abnormalities are frequent in spondylo-costal subtype. Neural tube defects with severe hydrocephalus are rare findings in this syndrome. Herein we report three infants with severe hydrocephalus associated with Jarcho-Levin syndrome.