Altered expression of p97/Valosin containing protein and impaired autophagy in preeclamptic human placenta.


ÖZSOY A. Z. , ÇAYLI S., Sahin C. , Ocakli S., Sanci T. , Ilhan D. B.

Placenta, cilt.67, ss.45-53, 2018 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

Özet

Introduction: Autophagy increases in placenta-related obstetrical diseases such as preeclampsia and intrauterine growth retardation but the regulation of autophagy by ubiquitin proteasome pathway (UPP) proteins, p97/Valosin containing protein (VCP) and ubiquitin (Ub) have not been previuosly studied in preeclampsia. The objective of this study is to investigate the expression of UPP (p97/VCP and Ub), autophagosomal (p62 and LC3) and autolysosomal proteins (Lamp1 and Lamp2) in the normal and preeclamptic human placentas and to explore the regulatory mechanism of these proteins in autophagic pathway.