Relationship between oxidant and antioxidant activity in hyperemesis gravidarum

Onaran Y., Kafali H., Duvan C. I., Keskin E., Çelik H., EREL Ö.

Journal of Maternal-Fetal and Neonatal Medicine, vol.27, no.8, pp.825-828, 2014 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 8
  • Publication Date: 2014
  • Doi Number: 10.3109/14767058.2013.842549
  • Journal Name: Journal of Maternal-Fetal and Neonatal Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.825-828
  • Keywords: Antioxidant activity, Hyperemesis gravidarum, Pregnancy
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Objective: To evaluate oxidant and antioxidant activity in patients with hyperemesis gravidarum (HG) by using serum total antioxidant activity (TAO), total free sulfhydryl (-SH), ceruloplasmin and lipid hydroperoxide (LOOH) levels. Materials and methods: In a cross-sectional trial, blood samples were collected from patients with HG (n=25) and healthy pregnant women (n=25) as control group. Serum TAO activities, -SH levels and LOOH levels and ceruloplasmin levels were measured. Results: Serum TAO activity was found to be significantly lower (p=0.003) in patients with HG compared with controls. However, serum -SH levels, LOOH levels and ceruloplasmin levels did not change significantly in patients with HG compared to controls. Conclusion: Presence of oxidative stress in HG patients depends more on reduced antioxidant activities than increased oxidative stress. © 2014 Informa UK Ltd.