Research Information System
Journal of Perinatal Medicine, vol.53, no.8, pp.1048-1053, 2025 (SCI-Expanded, Scopus)
Objectives: Preeclampsia is a multisystem syndrome that involves various genetic and environmental factors in its pathogenesis and pathophysiology. Its etiopathogenesis remains to be fully understood. This study aimed to investigate whether the level of pentraxin-3 (PTX3) in maternal peripheral blood during the second and third trimesters can predict its role in the aetiology of preeclampsia. Methods: This prospective study analysed data from 96 mothers who gave birth between September 2020 and 2021 at the Department of Obstetrics at Umraniye Training and Research Hospital. Blood PTX3 levels were measured for each participant. Of 96, 50 preeclampsia patients were in the study group, and 46 normotensive healthy pregnancies were in the control group. The associations between preeclampsia and PTX3 levels were investigated. Results: A total of 96 pregnant women were evaluated. The overall mean age was 28.9 ± 6.4years. As compared with mothers with healthy women, preeclampsia women had significantly a higher PTX3 level (5.919 ng/mL vs. 2.828 ng/mL, respectively; p=0.0001) in maternal peripheral blood. In addition, the PTX3 level was similar among varying forms of preeclampsia (p>0.05). In ROC analysis, the cut-off value for Pentraxin-3 to predict preeclampsia was established at 4.16 ng/mL, with a sensitivity of 95.9 %, a specificity of 97.8 %, a PPV of 97.9 % and an NPV of 95.7 %. Conclusions: Our findings suggest the expression of PTX3 in the peripheral blood was associated with the pathogenesis of PE. The PTX3 may prove useful in predicting preeclampsia in women with a PTX3 level higher than 4.16 ng/mL.