The effect of dust-mites on nitric oxide production


Yazar S., KILIÇ E., ATAMBAY M., Bay Karabulut A. , Aycan Ö. M. , Sönmez Tamer G., ...More

Turkish Journal of Medical Sciences, vol.39, no.1, pp.43-46, 2009 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 1
  • Publication Date: 2009
  • Title of Journal : Turkish Journal of Medical Sciences
  • Page Numbers: pp.43-46

Abstract

Aim: We aimed to investigate the effect of house dust mite on the level of nitric oxide in patients who had dust mite in their houses and suffering from rhinitis and/or asthma and/or eczema-like allergic symptoms and were positive for skin tests (Prick). Materials and Methods: The effect of dust-mites on nitric oxide concentration was investigated using Griess method in patients who had allergic symptoms and were positive for skin tests. Results: The plasma nitric oxide level was found to be statistically higher in patients who had dust mite in their houses and suffering from allergic symptoms and were positive for skin tests than in patients who did not have dust mite in their houses but were positive for skin tests or negative for skin tests. In addition, there was no statistical difference in the level of nitric oxide between the patients who did not have dust mite in their houses but were positive for skin tests and the patients who did not have dust mite in their houses and were negative for skin tests. Conclusions: There seems to be an effect of house dust mite on the level of nitric oxide. However, the molecular mechanism underneath of this effect is not yet clear. A plausible explanation for this might be the intrinsic radical properties of nitric oxide and its protective effect against the parasitic agents. © TÜBITAK.