Extramedullary orbital granulocytic sarcoma without bone marrow involvement: A report of two cases
Pediatric Hematology and Oncology, cilt.28, sa.1, ss.65-70, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 1
- Basım Tarihi: 2011
- Doi Numarası: 10.3109/08880018.2010.511439
- Dergi Adı: Pediatric Hematology and Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.65-70
- Anahtar Kelimeler: acute myeloid leukemia, children, granulocytic sarcoma
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır
Özet
The authors present herein 2 extramedullary orbital granulocytic sarcoma (GS) cases without bone marrow involvement in view of their rarity and also to reevaluate the treatment approach in this disease. Seven days of high-dose methyl prednisolone (HDMP) treatment (3 days 30 mg/kg/day and 4 days 20 mg/kg/day) was administered initially, and subsequently Acute Myeloid Leukaemia-Berlin Frankfurt Münster (AML-BFM) 2004 treatment protocol was continued for 2 cases. Eye findings of the cases resolved considerably with HDMP treatment. They have still been under systemic chemotherapy without any complication for 1 year. Thus, early diagnosis and AML-targeted intensive chemotherapy improve the prognosis of GS even if there is no bone marrow involvement. © 2011 Informa Healthcare USA, Inc.