Extramedullary orbital granulocytic sarcoma without bone marrow involvement: A report of two cases

Isik P., Tavil B., Tunç B., Yarali N. , Demir A., Çetin M.

Pediatric Hematology and Oncology, vol.28, no.1, pp.65-70, 2011 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.3109/08880018.2010.511439
  • Title of Journal : Pediatric Hematology and Oncology
  • Page Numbers: pp.65-70
  • Keywords: acute myeloid leukemia, children, granulocytic sarcoma


The authors present herein 2 extramedullary orbital granulocytic sarcoma (GS) cases without bone marrow involvement in view of their rarity and also to reevaluate the treatment approach in this disease. Seven days of high-dose methyl prednisolone (HDMP) treatment (3 days 30 mg/kg/day and 4 days 20 mg/kg/day) was administered initially, and subsequently Acute Myeloid Leukaemia-Berlin Frankfurt Münster (AML-BFM) 2004 treatment protocol was continued for 2 cases. Eye findings of the cases resolved considerably with HDMP treatment. They have still been under systemic chemotherapy without any complication for 1 year. Thus, early diagnosis and AML-targeted intensive chemotherapy improve the prognosis of GS even if there is no bone marrow involvement. © 2011 Informa Healthcare USA, Inc.