Oxidative stress and antioxidant imbalance in endometrial carcinogenesis Oxidační stres a nerovnováha antioxidantů v endometriální karcinogenezi
Ceska Gynekologie, cilt.91, sa.4, ss.306-313, 2026 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 91 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.48095/cccg2026306
- Dergi Adı: Ceska Gynekologie
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO)
- Sayfa Sayıları: ss.306-313
- Anahtar Kelimeler: endometrial cancer, oxidative stress, redox balance, thiol-disulfide homeostasis
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: To assess dynamic thiol-disulfide homeostasis as a biomarker of oxidative stress in patients with endometrial cancer and to evaluate its association with tumor grade and stage. Methods: This prospective case-control study included 35 patients with histopathologically-confirmed endometrial cancer and 36 age-matched healthy controls. Venous blood samples were obtained after overnight fasting. Serum thiol-disulfide homeostasis parameters were measured using a fully-automated spectrophotometric method. Native thiol, total thiol, disulfide concentrations, and related ratios were analyzed. Tumor grade and International Federation of Gynecology and Obstetrics stage were recorded for all patients. Results: Native thiol and total thiol levels were significantly lower in patients with endometrial cancer compared with healthy controls (both P < 0.001). Patients with grade 2 tumors exhibited significantly reduced native and total thiol levels compared with grade 1 patients and controls (P < 0.001). A significant inverse correlation was observed between tumor stage and thiol levels, with lower native and total thiol concentrations in stage IB compared with stage IA disease (R = −0.586, and R = −0.604, resp.; P < 0.001). Disulfide levels and thiol-disulfide ratios did not differ significantly between groups. Conclusion: Dynamic thiol-disulfide homeostasis is markedly impaired in endometrial cancer and is associated with tumor grade and stage. Reduced thiol levels reflect increased oxidative stress and diminished antioxidant capacity, suggesting that thiol-based redox parameters may serve as complementary biomarkers for disease severity and progression in endometrial cancer.