Comparison of Oxidant and Antioxidant Parameters in Patients with Sjögren's Syndrome and Healthy Subjects

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DOĞAN İ., ERTEN Ş., ŞAHİN A., Islkoglu S., NEŞELİOĞLU S., Ergin M., ...More

Aktuelle Rheumatologie, vol.45, no.6, pp.577-582, 2020 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.1055/a-1154-8623
  • Journal Name: Aktuelle Rheumatologie
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
  • Page Numbers: pp.577-582
  • Keywords: Oxidant/antioxidant status, paraoxonase, Sjögren's syndrome
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

© 2020. Thieme. All rights reserved.Objective Oxidative stress may have an effect on the pathogenesis of diseases, including autoimmune rheumatic diseases. We aimed to investigate the serum paraoxonase activity and other oxidant/antioxidant parameters in patients with Sjögren's syndrome (SS) and healthy controls. Methods 85 patients with SS and 65 healthy subjects were included in the study. Groups were age and gender-matched and had no liver disease. Serum paraoxonase (PON)-1 activity, stimulated paraoxonase (SPON), PON-1 phenotypes that represent polymorphism (Q192R; QQ, QR, RR), arylesterase (ARE), total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), advanced oxidative protein products (AOPP), total thioles (TTL) and ischaemia-modified albumin (IMA) were measured in all study participants. Results Statistically significant differences were found in the QQ and QR+RR phenotype of PON-1 for TAC, TOS and TTL (p<0.001) between SS and healthy groups. The other parameters were statistically insignificant. Conclusion Antioxidant parameters were lower in SS patients compared with healthy controls. Conversely, oxidant parameters were higher. This imbalance may play a role in SS pathogenesis.