Antimicrobial Activity of Garlic Derivatives on CommonCausative Microorganisms of the External Ear Canal andChronic Middle Ear Infections
TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY, vol.57, no.4, pp.161-165, 2019 (TRDizin)
- Publication Type: Article / Article
- Volume: 57 Issue: 4
- Publication Date: 2019
- Journal Name: TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY
- Journal Indexes: TR DİZİN (ULAKBİM)
- Page Numbers: pp.161-165
- Open Archive Collection: AVESIS Open Access Collection
- Ankara Yıldırım Beyazıt University Affiliated: No
Abstract
Objective: Today, antibiotic resistance is increasing and evolving into an important health problem.
Therefore, it is important to research on alternative
therapies to antibiotics. This study aimed to investigate the inhibitory effect of four garlic derivatives on
microorganisms commonly isolated in ear infections.
Methods: The antimicrobial activities of allicin, s-allyl
cysteine (SAC), diallyl disulfide (DADS), and s-allyl
mercaptocysteine (SAMC) were investigated on standard strains of commonly isolated microorganisms
using the broth microdilution method. The test strains
were selected among the microorganisms responsible
for chronic suppurative otitis media and otitis externa.
These microorganisms were Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter
baumannii, Staphylococcus aureus, Enterococcus faecium,
Candida albicans, and Candida tropicalis.
Results: Minimum inhibitory concentration (MIC)
values of allicin and SAC ranged from 0.125 to 20 μg/
mL for fermentative bacteria (E. coli and K. pneumoniae), 20 to 80 μg/mL for non-fermentative bacteria
(P. aeruginosa and A. baumannii), 5 to 10 μg/mL for
gram-positive cocci (S. aureus and E. faecium), and
40 to 80 μg/mL for yeasts (C. albicans and C. tropicalis). MIC values of DADS ranged from 40 to 80
μg/mL for fermentative bacteria, 40 to 160 μg/mL
for non-fermentative bacteria, 40 to 80 μg/mL for
gram-positive cocci, and 20 to 40 μg/mL for yeasts.
The MICs of SAMC were >640 μg/mL for the tested
bacteria and yeasts.
Conclusion: Both allicin and SAC showed antimicrobial activity against the tested microorganisms,
even at low concentrations. These two derivatives may
be used to treat infections in the future.
Keywords: Garlic, antimicrobial agent, chronic otitis
media, otitis externa, microbiologic technique