Transfusion-associated necrotising enterocolitis in very low birth weight premature infants

Demirel G., Celik I. H. , Aksoy H. T. , Erdeve O., Oguz S. S. , Uras N., ...More

TRANSFUSION MEDICINE, vol.22, no.5, pp.332-337, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1111/j.1365-3148.2012.01170.x
  • Title of Journal : TRANSFUSION MEDICINE
  • Page Numbers: pp.332-337


Objective Our aim was to determine the relationship between red blood cell transfusion and necrotising enterocolitis (NEC) in all admitted very low birth weight (VLBW) infants with or without transfusion. Study Design All VLBW neonates were categorised into five groups: (i) subjects that developed NEC <48?h after transfusion (n?=?15); (ii) subjects that developed NEC >48?h after transfusion (n?=?31); (iii) subjects that were never transfused but developed NEC, (n?=?50); (iv) subjects that were transfused but did not develop NEC, (n?=?250) and (v) subjects that were neither transfused nor developed NEC (n?=?301). Results A group of 647 infants were enrolled in the study. Mean gestational age and birth weight of the patients were 29 +/- 3.1?weeks and 1157 +/- 237?g, respectively. The mean age at the onset of NEC in the NEC groups were 20 +/- 2.3?days, 12 +/- 3?days and 11 +/- 2.6?days, respectively (P?