A comprehensive assessment of redox balance in small for gestational age newborns and their mothers
Lab Medicine, cilt.55, sa.2, ss.209-214, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 55 Sayı: 2
- Basım Tarihi: 2024
- Doi Numarası: 10.1093/labmed/lmad065
- Dergi Adı: Lab Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL
- Sayfa Sayıları: ss.209-214
- Anahtar Kelimeler: glutathione, oxidative stress, oxidized glutathione, redox, small for gestational age, thiol-disulfide homeostasis
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: The objective of this study was to assess oxidative stress in small for gestational age (SGA) newborns and their mothers by evaluating intra- and extracellular thiol homeostasis and the quantification of major oxidants and antioxidants. Methods: A total of 75 mothers and their 75 newborns (43 SGA) were enrolled in this study. Thiol-disulfide homeostasis, serum myeloperoxidase, catalase, total oxidant, and antioxidant status were analyzed. Additionally, erythrocytic glutathione (GSH) homeostasis was measured. Results: Although native and total thiol levels were decreased, disulfide levels were increased in SGA groups. Additionally, myeloperoxidase activity and total oxidant status levels were significantly elevated whereas total antioxidant status levels and enzymatic antioxidant systems were diminished in SGA groups. Similarly, intra-erythrocytic GSH homeostasis was shifted in favor of oxidants in SGA groups. Conclusion: Our results demonstrate that insufficient antioxidant systems in mothers and a robust source of oxidative stress in SGA might contribute to the pathophysiology of SGA births.