Protein C and protein S activities in Behcet's disease as risk factors of thrombosis

Lenk N., Özet G., Alli N., Çoban Ö., Erba̧i S.

International Journal of Dermatology, vol.37, no.2, pp.124-125, 1998 (SCI-Expanded) identifier identifier


Background: In Behcet's disease (BD), there is a marked increase in vascular complications. Approximately 30% of patients with BD suffer from thrombosis of the arteries and veins, varices, aneurysms, and thrombophlebitis of superficial or deep veins. Protein C and Protein S are major inhibitors of coagulation, and it is well know that the deficiency of Protein C and Protein S causes thrombotic disorders. Methods: Protein C and Protein S activities were measured in 23 patients with BD and in a control group consisting of 23 age- and sex-matched healthy volunteers. Patients who had received anticoagulant or oral contraceptive drugs, or who had liver disease or active thrombosis, were not included in the study. Results: Of the 23 patients with BD (age, 13-55 years), the mean Protein S activities (94.2 ± 11.3%) were slightly lower than the means of the control group (109.1 ± 8.4%), but not statistically significant differences could be demonstrated (p > 0.05). Compared with the means of the control group (103.5 ± 6.9%), the Protein C activities were not lower in BD (106.3 ± 8.4%). No statistical difference was determined. Conclusions: Protein C and Protein S deficiencies are not a probable cause of thrombotic manifestations in BD. We do not recommend the measurement of these activities routinely in BD unless thrombosis is the major and primary manifestation of BD.