47D11 Antibody-Engineered Exosomes for Targeted Delivery of Remdesivir in Patients with COVID-19: Dream or Principle? (A Critical Editorial Study)

Daneshi N., Esmaeilzadeh A., Bahmaie N.

Eurasian Journal of Medicine, vol.54, no.3, pp.310-312, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Letter
  • Volume: 54 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.5152/eurasianjmed.2022.21116
  • Journal Name: Eurasian Journal of Medicine
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.310-312
  • Keywords: COVID-19, exosomes, mesenchymal stem cells, regenerative medicine, remdesivir, targeted therapy
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


© 2022, AVES. All rights reserved.Along with the high transmission rate of coronavirus disease 2019 infection in the last few months, the morbidity and mortality rate of coronavirus disease 2019 has been increased among critically-ill patients, especially the elderly or the ones with immunodeficiencies. So, there is an urgent need to develop more effective therapeutic agents through immunopathophysiological and immunotherapeutic-based strategies for these patients. Here, we hypothesize that mixing S1b-RBD-expressing mesenchymal stem cell-derived exosomes (which have been previously enriched with Remdesivir) with 47D11 antibody, can promisingly guarantee effective transferring of those targeted exosomes to the targeted microenvironment of coronavirus disease 2019 infection. In addition, it can induce their immunomodulatory properties, and anti-viral features, refrain-ing from entrance of severe acute respiratory syndrome-related coronavirus-2 to angiotensin-converting enzyme 2-expressing cells.