Role of oxidative and antioxidative parameters in etiopathogenesis and prognosis of panic disorder

Ersoy M. A., Selek S., Celik H., EREL Ö., Kaya M. C., Savas H. A., ...More

International Journal of Neuroscience, vol.118, no.7, pp.1025-1037, 2008 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 7
  • Publication Date: 2008
  • Doi Number: 10.1080/00207450701769026
  • Journal Name: International Journal of Neuroscience
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1025-1037
  • Keywords: Antioxidant activity, Ceruloplasmin, Free radical, Oxidative stress, Panic disorder, Sulphydryl
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Free radicals have been implicated in some psychiatric disorders. This study aimed to investigate the role of oxidative and antioxidative parameters in etiopathogenesis and prognosis of panic disorder (PD), using novel methods for measurement of total oxidant and antioxidant statuses. Nineteen PD patients and 40 healthy subjects were recruited. Both total antioxidant status and oxidative stress index, and ceruloplasmin levels of PD patients were significantly higher in PD patients. Total oxidant status and oxidative stress index decreased after treatment. This study suggests an oxidative imbalance in PD and treatment can reverse overall oxidative imbalance. Copyright © 2008 Informa Healthcare USA, Inc.