Phenotypic variants of paraoxonase Q192R in bipolar disorder, depression and schizophrenia

Atagun M. I., TUNÇ S., Alisik M. İ., Erel O.

Turk Psikiyatri Dergisi, vol.29, no.2, 2018 (SSCI, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5080/u21611
  • Journal Name: Turk Psikiyatri Dergisi
  • Journal Indexes: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Objective: Activity of the paraoxonase 1 (PON1) enzyme varies prominently according to the PON1 Q192R genotype. The arginine (R) genotype hydrolyzes peroxided lipids more quickly and efficiently than the glutamine (Q) genotype. The Q phenotype suggests greater liability to neurodegenerative processes, cardiovascular and malignancy risks than the R phenotype. Stimulated PON/ARES ratio is associated with the PON1 Q192R polymorphism. This study aimes to assess the Q192R phenotype in schizophrenia, bipolar disorder and depression.