Phenotypic variants of paraoxonase Q192R in bipolar disorder, depression and schizophrenia
Turk Psikiyatri Dergisi, cilt.29, sa.2, 2018 (SSCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.5080/u21611
- Dergi Adı: Turk Psikiyatri Dergisi
- Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: Activity of the paraoxonase 1 (PON1) enzyme varies prominently according to the PON1 Q192R genotype. The arginine (R) genotype hydrolyzes peroxided lipids more quickly and efficiently than the glutamine (Q) genotype. The Q phenotype suggests greater liability to neurodegenerative processes, cardiovascular and malignancy risks than the R phenotype. Stimulated PON/ARES ratio is associated with the PON1 Q192R polymorphism. This study aimes to assess the Q192R phenotype in schizophrenia, bipolar disorder and depression.