Phenotypic variants of paraoxonase Q192R in bipolar disorder, depression and schizophrenia


Atagun M. I. , TUNÇ S., Alisik M. İ. , Erel O.

Turk Psikiyatri Dergisi, vol.29, no.2, 2018 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5080/u21611
  • Title of Journal : Turk Psikiyatri Dergisi

Abstract

Objective: Activity of the paraoxonase 1 (PON1) enzyme varies prominently according to the PON1 Q192R genotype. The arginine (R) genotype hydrolyzes peroxided lipids more quickly and efficiently than the glutamine (Q) genotype. The Q phenotype suggests greater liability to neurodegenerative processes, cardiovascular and malignancy risks than the R phenotype. Stimulated PON/ARES ratio is associated with the PON1 Q192R polymorphism. This study aimes to assess the Q192R phenotype in schizophrenia, bipolar disorder and depression.