Poly(ADP-ribose) Polymerase inhibition improves wound healing in the colonic anastomoses of rats

Ersoz, N.; Poyrazoglu, Y.; Yuksel, R.; Uysal, B.; Topal, T.; Tuncer, S.; Gocgeldi, E.; Korkmaz, A.

doi:10.1007/s10353-015-0365-1

Poly(ADP-ribose) Polymerase inhibition improves wound healing in the colonic anastomoses of rats

Ersoz N., Poyrazoglu Y., Yuksel R., Uysal B., Topal T., Tuncer S. K., ...Daha Fazla

EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA, cilt.48, sa.2, ss.115-121, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 48 Sayı: 2
Basım Tarihi: 2016
Doi Numarası: 10.1007/s10353-015-0365-1
Dergi Adı: EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.115-121
Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet

Özet

Colonic anastomosis is a widely used surgical procedure and leads to morbidity and mortality with anastomotic leaks. It has been shown that PARP inhibition has beneficial effects against various pathological conditions. In this study, we aimed to evaluate the possible effects of 3-aminobenzamide (3-AB), a PARP-1 inhibitor, on experimental wound healing and tensile strength in the colonic anastomosis of rats.