Poly(ADP-ribose) Polymerase inhibition improves wound healing in the colonic anastomoses of rats


Ersoz N., Poyrazoglu Y., Yuksel R., Uysal B., Topal T., Tuncer S. K. , ...More

EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA, vol.48, no.2, pp.115-121, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1007/s10353-015-0365-1
  • Title of Journal : EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
  • Page Numbers: pp.115-121

Abstract

Colonic anastomosis is a widely used surgical procedure and leads to morbidity and mortality with anastomotic leaks. It has been shown that PARP inhibition has beneficial effects against various pathological conditions. In this study, we aimed to evaluate the possible effects of 3-aminobenzamide (3-AB), a PARP-1 inhibitor, on experimental wound healing and tensile strength in the colonic anastomosis of rats.