Poly(ADP-ribose) Polymerase inhibition improves wound healing in the colonic anastomoses of rats


Ersoz N., Poyrazoglu Y., Yuksel R., Uysal B., Topal T., Tuncer S. K. , ...Daha Fazla

EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA, cilt.48, sa.2, ss.115-121, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 48 Konu: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10353-015-0365-1
  • Dergi Adı: EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
  • Sayfa Sayıları: ss.115-121

Özet

Colonic anastomosis is a widely used surgical procedure and leads to morbidity and mortality with anastomotic leaks. It has been shown that PARP inhibition has beneficial effects against various pathological conditions. In this study, we aimed to evaluate the possible effects of 3-aminobenzamide (3-AB), a PARP-1 inhibitor, on experimental wound healing and tensile strength in the colonic anastomosis of rats.