Association of Thiol Disulfide Homeostasis with Childhood Asthma


Kaya B. K. , AYDIN M., Donma M. M. , Demirkol M., BİÇER C. , EREL Ö.

JOURNAL OF PEDIATRIC BIOCHEMISTRY, vol.6, no.3, pp.152-155, 2016 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1055/s-0036-1597607
  • Title of Journal : JOURNAL OF PEDIATRIC BIOCHEMISTRY
  • Page Numbers: pp.152-155

Abstract

The aim of this study is to evaluate the oxidative stress level in asthmatic children in terms of the disulfide/thiol ratio, to research the role the disulfide/thiol ratio plays in the pathogenesis of the malady, and to determine the usefulness of the disulfide/thiol ratio as an indicator of the oxidation stress situations in patients with asthma. We report that the disulfide/thiol ratio and disulfide levels were significantly higher in the asthmatic group than in the control group. All in all, high levels of disulfide/thiol ratios in asthmatic children are thought to play roles in the pathogenesis of the disease.