Association of Thiol Disulfide Homeostasis with Childhood Asthma

Kaya B. K. , AYDIN M., Donma M. M. , Demirkol M., BİÇER C. , EREL Ö.

JOURNAL OF PEDIATRIC BIOCHEMISTRY, cilt.6, sa.3, ss.152-155, 2016 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1055/s-0036-1597607
  • Sayfa Sayıları: ss.152-155


The aim of this study is to evaluate the oxidative stress level in asthmatic children in terms of the disulfide/thiol ratio, to research the role the disulfide/thiol ratio plays in the pathogenesis of the malady, and to determine the usefulness of the disulfide/thiol ratio as an indicator of the oxidation stress situations in patients with asthma. We report that the disulfide/thiol ratio and disulfide levels were significantly higher in the asthmatic group than in the control group. All in all, high levels of disulfide/thiol ratios in asthmatic children are thought to play roles in the pathogenesis of the disease.