© 2021 Taylor & Francis Group, LLC.Premenstrual syndrome (PMS) is a common health problem that adversely affects young women’s quality of life. This paper evaluated the effectiveness of a “Training Program for Coping with PMS Symptoms based on Information-Motivation-Behavioral Skills (IMB) model” in university nursing students. This controlled intervention study was conducted between September 2017 and February 2018. No sampling was performed. The goal was to include all students who met the inclusion criteria. The sample consisted of 95 first-year nursing students from two universities divided into two groups: intervention (n = 40) and control (n = 45) (power of 84.5%, p = .05, effect size = 0.45). The intervention group received the training, followed by individual motivational counseling first and second months after the training. The control group did not participate in the training program. The intervention group had more PMS symptoms coping behaviors (recognizing premenstrual change, performing regular exercises, relaxation techniques, pursuing a healthy diet, communicating with family and friends) than their counterparts in the control group after the training program (p < .05). The intervention group had higher Premenstrual Coping Measure scores (recognizing premenstrual changes, performing self-care, avoiding harm, communicating) after training program (p < .05). Although habits are hard to break, especially at young ages, the training helped university students adopt PMS coping behaviors.