Modified Proline Metabolism and Prolidase Enzyme in COVID-19

Ergin Tuncay M., Neselioglu S., Asfuroglu Kalkan E., Inan O., Sena Akkus M. S., Ates I., ...More

Lab Medicine, vol.53, no.5, pp.453-458, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1093/labmed/lmac017
  • Journal Name: Lab Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.453-458
  • Keywords: copper, COVID-19, glutamic acid, prolidase, proline, zinc
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Objective: The aim of the study was to evaluate proline metabolism in patients affected by COVID-19. Materials and Methods: This case-control study consisted of 116 patients with COVID-19 and 46 healthy individuals. Tests related to proline metabolism (prolidase, proline, hydroxyproline, glutamic acid, manganese) and copper and zinc tests were analyzed. Results: The levels of proline and hydroxyproline amino acids and the prolidase enzyme were found to be lower and glutamic acid was found to be higher in the COVID-19 group compared to the healthy group (P = .012, P <. 001, P <. 001, and P <. 001, respectively). The copper/zinc ratio was higher in patients with COVID-19 than in healthy individuals (P <. 001). Significant correlations were found between proline metabolism tests and inflammatory and hemostatic markers commonly used in COVID-19. Conclusion: The proline metabolic pathway was affected in COVID-19. Relationships between proline pathway-related tests and inflammatory/hemostatic markers supported the roles of proline metabolism in proinflammatory and immune response processes.