Extraction, Characterization, and Biocompatibility Evaluation of Type I Collagen from Chicken Feet Skin
Biomedical Materials and Devices, cilt.3, sa.2, ss.1448-1462, 2025 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 3 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.1007/s44174-024-00266-1
- Dergi Adı: Biomedical Materials and Devices
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1448-1462
- Anahtar Kelimeler: Biocompatibility, Chicken foot skin, Type I collagen extraction
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Abstract: The study focused on extracting type I collagen, a protein derived from chicken feet skin, for applications in the biomedical and cosmetic industries. The research thoroughly explored the extraction methodology and characterization techniques and assessed the biocompatibility of the collagen. Acid extraction yielded substantial amounts of type I collagen with an efficiency of 11.35%. The characterization process involved various analyses, including FTIR, SDS-PAGE, western blot, and SEM imaging, to evaluate purity, structural integrity, and morphology. In vitro testing confirmed the biocompatibility of the extracted collagen, indicating its potential as a natural polymer for medical studies. The collagen extracted from chicken feet skin demonstrated significant bioactivity, positioning it as a promising polymer for tissue engineering, wound healing, and cosmetic applications. This study underlines the importance of developing biocompatible biomaterials and provides valuable insights into a sustainable source of collagen from animal by-products.