Background: Various algorithms and treatment guidelines have been established for the treatment of neuropathic pain. In summary, tricyclic antidepressants, anticonvulsants, serotonin reuptake inhibitors and opioids are used in these algorithms. Pregabalin is an anticonvulsant drug that is frequently used in the treatment of neuropathic pain. During the use of kidneys in patients with renal insufficiency due to the need to change the dose was taken attention. Therefore, in our study, we aimed to investigate the effects of pregabalin on renal tissue in rats with renal failure due to ureter obstruction.