How to manage poor mobilizers for high dose chemotherapy and autologous stem cell transplantation?

Ataca Atilla P., Bakanay Ozturk Ş. M., DEMİRER T.

Transfusion and Apheresis Science, vol.56, no.2, pp.190-198, 2017 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Review
  • Volume: 56 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1016/j.transci.2016.11.005
  • Journal Name: Transfusion and Apheresis Science
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.190-198
  • Keywords: Autologous hematopoietic stem cell transplantation, Chemotherapy, G-CSF, Plerixafor, Poor mobilizers
  • Ankara Yıldırım Beyazıt University Affiliated: No

Abstract

Today, peripheral blood stem cells are the preferred source of stem cells over bone marrow. Therefore, mobilization plays a crutial role in successful autologous stem cell transplantation. Poor mobilization is generally defined as failure to achieve the target level of at least 2 × 106 CD34+ cells/kg body weight. There are several strategies to overcome poor mobilization: 1) Larger volume Leukapheresis (LVL) 2) Re-mobilization 3) Plerixafor 4) CM + Plerixafor (P) + G-CSF and 5) Bone Marrow Harvest. In this review, the definitions of successful and poor mobilization are discussed. Management strategies for poor mobilization are defined. The recent research on new agents are included.