Cardiovascular protective effect of pioglitazone on oxidative stress in rats with metabolic syndrome


Bilginoglu A.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, vol.82, no.6, pp.452-456, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.1097/jcma.0000000000000103
  • Title of Journal : JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
  • Page Numbers: pp.452-456

Abstract

Background: Although cardiovascular oxidative stress is examined in type 2 diabetes, there is relatively limited number of reports about the effect of pioglitazone, an insulin sensitizer, on cardiovascular oxidative stress in sucrose diet-induced metabolic syndrome (MetS). As a regulator of cardiovascular homeostasis, thioredoxin (TRX) has an important role in defense against oxidative stress in cardiovascular diseases. The purpose of this study is to investigate the role of pioglitazone on oxidative stress markers and TRX1 level in tissues of both heart and aorta from MetS rats.