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International Journal of Dermatology, vol.44, no.8, pp.636-640, 2005 (SCI-Expanded)
Background: Several groups have shown the involvement of oxidative stress in the pathophysiology of vitiligo. Methods: In this study, we examined the erythrocyte and plasma activities of glutathione peroxidase and Cu/Zn superoxide dismutase, plasma nitrite/nitrate levels, and erythrocyte catalase activity in 23 vitiligo patients and 25 controls. Results: The results show that erythrocyte superoxide dismutase activity and plasma nitrite/nitrate levels are high in vitiligo patients. Conclusions: Our study confirms that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the high levels of erythrocyte superoxide dismutase activity and plasma nitrite/nitrate. © 2004 The International Society of Dermatology.