A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients
International Journal of Dermatology, cilt.44, sa.8, ss.636-640, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 44 Sayı: 8
- Basım Tarihi: 2005
- Doi Numarası: 10.1111/j.1365-4632.2004.02027.x
- Dergi Adı: International Journal of Dermatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.636-640
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır
Özet
Background: Several groups have shown the involvement of oxidative stress in the pathophysiology of vitiligo. Methods: In this study, we examined the erythrocyte and plasma activities of glutathione peroxidase and Cu/Zn superoxide dismutase, plasma nitrite/nitrate levels, and erythrocyte catalase activity in 23 vitiligo patients and 25 controls. Results: The results show that erythrocyte superoxide dismutase activity and plasma nitrite/nitrate levels are high in vitiligo patients. Conclusions: Our study confirms that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the high levels of erythrocyte superoxide dismutase activity and plasma nitrite/nitrate. © 2004 The International Society of Dermatology.