Can the triglyceride-glucose index predict insulin resistance in LGA newborns?
Journal of Perinatology, cilt.43, sa.9, ss.1119-1124, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 9
- Basım Tarihi: 2023
- Doi Numarası: 10.1038/s41372-022-01586-0
- Dergi Adı: Journal of Perinatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, MEDLINE
- Sayfa Sayıları: ss.1119-1124
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Background: The aim of this study is to investigate the TyG index and TG/HDL-C ratio and their relationships with insulin resistance in LGA infants. Methods: A prospective controlled study was conducted including 65 LGA and gestational age, gender-matched appropriate for gestational age (AGA) neonates. Serum TG, total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), insulin and glucose levels were measured within two hours after birth, TyG index and HOMA-IR values were calculated. Results: TyG index and TG/HDL- C ratio were higher in LGA neonates compared to AGA ones (p = 0.03; p = 0.00, respectively). Compared with AGA newborns, LGA newborns had higher levels of insulin and HOMA-IR (p = 0.00; p = 0.00, respectively). TyG index and TG/HDL-C ratio showed moderate correlation with HOMA-IR (r = 0.59 R2 = 0.35 p < 0.001; r = 0.5 R2 = 0.25 p < 0.001, respectively). Conclusıon: The results of this study show that LGA newborns have increased levels of TyG index and TG/HDL-C associated with insulin resistance.