Mean platelet volume is increased in patients with bicuspid aortic valve

Bilen E., Tanboga I. H., Kurt M., Kocak U., Ayhan H., DURMAZ T., ...More

Clinical and Applied Thrombosis/Hemostasis, vol.18, no.4, pp.351-355, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1177/1076029611427439
  • Journal Name: Clinical and Applied Thrombosis/Hemostasis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.351-355
  • Keywords: bicuspid aortic valve, platelet function
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Background: It has been demonstrated that platelet activation occurs in patients with aortic stenosis. However, no study has assessed platelet activation in patients with a normally functioning bicuspid aortic valve (BAV). Therefore, we aimed to investigate relationship between platelet activation assessed by mean platelet volume (MPV) and normally functioning BAV. Methods: Thirty-nine patients with isolated BAV and 25 age- and gender-matched healthy participants were included in the study. Patients with more than mild aortic regurgitation and aortic velocity >2 m/s were excluded from the study. For the entire study population, MPV was measured using an automatic blood counter. Results: Compared to control group, MPV value was significantly higher in patients with BAV (8.6 ± 1.0 vs 8.0 ± 0.8, p:.01). In the correlation analysis, there was a significant correlation between MPV measures with aortic stiffness (r:.32 and p:.01) and aortic elastic modulus (r:.37 and p:.003). Conclusion: Our study results indicate that BAV is associated with elevated MPV values. © The Author(s) 2012.