Evaluation of salivary total oxidant-antioxidant status and DNA damage of children undergoing fixed orthodontic therapy

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Guler C., Toy E., Ozturk F., Gunes D., Karabulut A., Otlu O.

Angle Orthodontist, vol.85, no.2, pp.239-244, 2015 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 85 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.2319/110113-798.1
  • Journal Name: Angle Orthodontist
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.239-244
  • Keywords: 8-Hydroxy-2′-deoxyguanosine, Total antioxidant status, Total oxidant status
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara Yıldırım Beyazıt University Affiliated: No

Abstract

© 2015 by The EH Angle Education and Research Foundation, Inc.Objective: To determine the total oxidant status (TOS), total antioxidant status (TAS), and the 8- hydroxy-2′-deoxyguanosine (8-OHdG) levels and their interrelationship in the saliva of children undergoing fixed orthodontic therapy. Materials and Methods: Thirty children were randomly divided into three groups. The attachments were bonded to all of the teeth using three different orthodontic composites: Transbond XT, Kurasper F, and GrenGloo. The salivary levels of TOS, TAS, and 8-OHdG were determined three times, as follows: before treatment (T1) and at 1 month (T2) and 3 months (T3) following appliance placement. All data were statistically analyzed. Results: There were no significant differences in TOS, TAS, and 8-OHdG within the same time periods among the three different orthodontic composites (P > .05). TAS in all composite groups decreased over time. These decreases were found to be significant for Kurasper F and GrenGloo at the T1-T3 and T2-T3 time periods (P < .05). In all composite groups 8-OHdG decreased between T1 and T2 (P < .05). However, 8-OHdG in all composite groups increased from T2 to T3. These differences in 8-OHdG were significant in Kurasper F and GrenGloo (P < .05). Conclusions: Fixed orthodontic appliances bonded with the tested composites did not increase the cytotoxicity markers in saliva.