Evaluation of serum TWEAK concentration in patients with acute pancreatitis


Koçak E., Köklü S., Başar Ö., Yilmaz F. M. , Çiftçi A., Kaya C., ...More

Scandinavian Journal of Clinical and Laboratory Investigation, vol.72, no.3, pp.192-196, 2012 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.3109/00365513.2011.629678
  • Journal Name: Scandinavian Journal of Clinical and Laboratory Investigation
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.192-196
  • Keywords: Acute pancreatitis, Biomarker, Concentration, Diagnosis, TWEAK

Abstract

Background and Aim: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor super family of structurally-related cytokines. The aim of this study was to determine the diagnostic and prognostic role of serum TWEAK concentration in patients with acute pancreatitis. Methods; Twenty four patients with acute pancreatitis and 24 consecutive healthy age- and sex-matched control subjects were included in the study. The serum concentrations of TWEAK were measured at admission and then at remission. The average time between admission and remission was 7-10 days. Results: At admission, TWEAK concentration was significantly lower in patients with acute pancreatitis compared to control subjects (p < 0.001). Serum TWEAK concentrations were elevated after the remission period, however the differences were not statistically significant. In addition, serum TWEAK concentration showed a significant, inverse correlation with amylase, lipase, CRP, AST, fibrinogen, LDH and a positive correlation with calcium, albumin and platelet count. Conclusions: Patients with acute pancreatitis have lower serum TWEAK concentration than healthy subjects. These results suggest that serum TWEAK concentration could be a potential biomarker of acute pancreatitis. © 2012 Informa Healthcare.