In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates to vancomycin, teicoplanin, linezolide and daptomycin Metisiline dirençli staphylococcus aureus izolatlarinin vankomisin, teikoplanin, linezolid ve daptomisine in vitro duyarliliklari
Mikrobiyoloji Bulteni, cilt.45, sa.3, ss.512-518, 2011 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 3
- Basım Tarihi: 2011
- Dergi Adı: Mikrobiyoloji Bulteni
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.512-518
- Anahtar Kelimeler: Daptomycin, Linezolide, Methicillin-resistant Staphylococcus aureus, Susceptibility, Teicoplanin, Vancomycin
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır
Özet
In this study, vancomycin, teicoplanin, linezolide and daptomycin susceptibility rates of 67 methi-cillin-resistant Staphylococcus aureus (MRSA) isolates obtained from various clinical samples between November 2006 and August 2010 in our laboratories, were investigated by E-test method and MIC values of the drugs were determined. Seventeen (25%) of the samples were from outpatient wards, 50 (75%) from inpatients of which 24 (48%) were from intensive care units. Distribution of MRSA isolated clinical samples were as follows: 16 (23.4%) blood, 28 (42.2%) wound swab, 15 (21.8%) tracheal aspirate, 2 (3.1%) urine, 2 (3.1%) urethral discharge, and one for each (1.6%) cerebrospinal fluid, joint fluid, catheter tip and nasal swab. Except one (1.5%) which was probably intermediate-resistant to vancomycin (since not confirmed by microdilution test or population analysis, this isolate was considered as "probable" intermediate-resistant), all of the isolates were found susceptible to all tested antibiotics. MIC 50 and MIC 90 values were determined as 0.75 and 1.5 μ/ml for vancomycin, 2 and 3 μg/ml for teicoplanin, 0.38 and 0.5 μg/ml for linezolide and 0.094 and 0.19 μg/ml for daptomycin, respectively. The MIC ranges were 0.25-3 μg/ml for vancomycin, 0.125-4 μg/ml for teicoplanin, 0.094-3 μg/ml for linezolide and 0.047-0.25 μg/ml for daptomycin. There was no statistically significant difference between MICs of outpatient, inpatient and intensive care unit isolates for any of the tested drugs (p> 0.05). Based on MIC 90 values, daptomycin seems 4-16 times more effective than the other three drugs. It was concluded that considering their in-vitro antibacterial activity, these antibiotics can be used as alternatives to each other for the treatment of MRSA infections.