How do thiol disulfide balance and copper-ceruloplasmin levels change in women using copper intrauterine devices?

KORKMAZ H., Deveci C. D. , Alışık M., Korkmaz V., KURDOĞLU Z., EREL Ö., ...More

Gynecological Endocrinology, 2022 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1080/09513590.2022.2089650
  • Journal Name: Gynecological Endocrinology
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Keywords: ceruloplasmin, ceruloplasmin ferroxidase activity, Copper, Cu-IUD, oxidative stress, thiol-disulfide homeostasis


© 2022 Informa UK Limited, trading as Taylor & Francis Group.Objectives: We aimed to examine the change in plasma copper (Cu) level and copper transport proteins level before inserting Cu-IUD and after one menstrual cycle and to show the effect of this change on the thiol disulfide balance in women using copper-containing intrauterine device (Cu-IUD). Method: Thirty-three reproductive women who admitted to the gynecology clinic and inserted Cu-IUD were examined in this study. Thiol-disulfide homeostasis, plasma Cu and ceruloplasmin levels and ceruloplasmin ferroxidase activity were measured using the blood samples collected just before inserting Cu-IUD and after one menstrual cycle. Results: Plasma copper level (p = 0.006), ceruloplasmin (p < 0.001), Ceruloplasmin Ferroxidase (p = 0.005), thiol disulfide homeostasis parameters; native thiol (NT) (p = 0.004), and total thiol (p = 0.003) levels increased significantly. Conclusion: After one menstrual cycle in women inserted intrauterine Cu-IUD for contraception, plasma levels of Cu, which is the oxidant molecule, increased significantly. Both plasma ceruloplasmin level and ceruloplasmin ferroxidase activity increased due to elevated Cu levels. This increased oxidant status in the acute period was balanced by the increase in the native thiol level.