Research Information System
International Journal of Ophthalmology, vol.7, no.2, pp.317-320, 2014 (SCI-Expanded, Scopus)
AIM To compare the corneal parameters of children with congenital isolated growth hormone deficiency and healthy subjects. METHODS In this cross-sectional, prospective study, 50 cases with growth hormone (GH) deficiency treated with recombinant GH and 71 healthy children underwent a complete ophthalmic examination. The corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) were measured with the Ocular Response Analyzer (ORA). Central corneal thickness (CCT) was measured by a ultrasonic pachy meter. RESULTS Themeanagewasi3.o±3.oyearsintheGH deficiency group consisting of 2 1 females and 29 males and 13.4 ±2.4 yearsin the healthy children group consisting of 41 females and 30 males. Therewasno statistically significant difference between the groups for gender or age (Chi-square test, P=o.O9; independent t-test, P=o.28, respectively). The mean duration of recombinant GH therapy was 3.8±2.4y in the study group. The mean CH, CRF, IOPg and IOPcc values wereii.o±2.o, io.9±i.9, 15.1 ±3 .3, and 15.1 ±3.2 mm Hg respectively in the study group. The same values were io.7±i .7, 10.5 ±1.7, 15.2 ±3.3, and 15.3 ±3.4 mm Hg respectively in the control group. The mean CCT values were555.7±40.6, 545.1 ±32.5 |am in the study and control groups respectively. Therewasno statistically significant difference between the two groups for CH, CRF, IOPg, IOPcc measurements or CCT values (independent t-test, P=o.3 15, 0.286, 0.145, -747, 0.13 respectively). CONCLUSION Our study suggests that GH deficiency does not have an effect on the corneal parameters and CCT values. This observation could be because of the duration between the beginning of disease and the diagnosis and beginning of GH therapy . © International Journal of Ophthalmology Press.