Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy
Journal of Assisted Reproduction and Genetics, cilt.28, sa.3, ss.245-251, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1007/s10815-010-9502-8
- Dergi Adı: Journal of Assisted Reproduction and Genetics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.245-251
- Anahtar Kelimeler: Clinical pregnancy, Follicular fluid, IL-6, IVF
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır
Özet
Purpose: Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles. Methods: Follicular fluid was collected from ovarian follicles ≥∈14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n∈=∈68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses. Results: Significant positive correlations were observed between IL-6 with age (p∈=∈0.035), and IL-6 with estradiol on the day of hCG (p∈=∈0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0 pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy (p∈=∈0.045). Conclusions: Lower follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels. © 2010 Springer Science+Business Media, LLC.