Kaplankıran C., Soyyiğit Ş., Özdel Öztürk B., Görgülü Akın B., Bayrak Durmaz M. S., Öztürk Aktaş Ö., ...Daha Fazla
CENTRAL-EUROPEAN JOURNAL OF IMMUNOLOGY, cilt.51, sa.4, ss.1-10, 2026 (SCI-Expanded, Scopus)
-
Yayın Türü:
Makale / Tam Makale
-
Cilt numarası:
51
Sayı:
4
-
Basım Tarihi:
2026
-
Doi Numarası:
10.5114/ceji/213652
-
Dergi Adı:
CENTRAL-EUROPEAN JOURNAL OF IMMUNOLOGY
-
Derginin Tarandığı İndeksler:
Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Health Research Premium Collection (ProQuest), Scopus, Pharma Collection (ProQuest), Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, EMBASE, Directory of Open Access Journals
-
Sayfa Sayıları:
ss.1-10
-
Ankara Yıldırım Beyazıt Üniversitesi Adresli:
Evet
Özet
Introduction
Common variable immunodeficiency (CVID) presents with diverse clinical and immunological manifestations. This study aimed to investigate the relationships between clinical phenotypes and immunological profiles in an adult CVID cohort.
Material and Methods
We retrospectively evaluated demographic and clinical features, infectious/non-infectious complications, immunological parameters, and flow cytometric findings in 32 adult patients (aged ≥ 18 years; 14 female, 18 male) diagnosed with CVID.
Results
Based on clinical phenotypes and organ system involvement, three clusters were identified: Cluster 1 (n = 10, 31.2%) was characterized by dominant infectious phenotype; Cluster 2 (n = 8, 25.0%) featured infectious manifestations but lacked lymphoproliferation; allergic conditions were relatively more common; and Cluster 3 (n = 14, 43.8%) was distinguished by dominant autoimmune features and lymphoproliferation. The most frequently observed cluster in our patient cohort was Cluster 3. The most significant predictors in the clustering analysis were lymphoproliferation, autoimmunity, and infection. The percentage of CD4+CD45RO+ cells was significantly higher in patients without infections, whereas the percentage of CD8+CD45RO+ cells was higher in those with infections (p = 0.007 and 0.003, respectively). Among patients with autoimmunity, CD8+CD45RO+ percentages were lower and CD21lowCD38low B cell populations were higher compared to those without autoimmunity (p = 0.005 and p = 0.047, respectively).
Conclusions
This study highlights infection, autoimmunity, and lymphoproliferation as prominent phenotypic features in CVID and reveals distinct immune cell profiles among these phenotypes. These findings may provide valuable guidance for improving diagnostic processes and patient management in CVID.