The safety and efficacy of remifentanil compared to fentanyl in pediatric endoscopy

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Gül R., Hizli Ş. , Kocamer B., Koruk S., Şahin L., Kilinçaslan H., ...More

Turkish Journal of Medical Sciences, vol.43, no.4, pp.611-616, 2013 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.3906/sag-1208-3
  • Title of Journal : Turkish Journal of Medical Sciences
  • Page Numbers: pp.611-616


Aim: To compare propofol combinations with low induction doses of remifentanil and fentanyl in respect to the complication frequency and efficiency in ease of procedure in children undergoing esophagogastroduodenoscopy. Materials and methods: Sixty-four patients, aged 3-14 years and undergoing elective esophagogastroduodenoscopy, were included in the study. The patients received an induction dose of 0.25 μg kg-1 remifentanil and 2 mg kg-1 propofol (group R), or 0.5 μg kg-1 fentanyl and 2 mg kg-1 propofol (group F) before the procedure. The procedure began with a sedation score of ≥5. Hemodynamic values, movement, ease and duration of the procedure, the time to awakening, and any requirement for additional doses of propofol/opioids and adverse events were recorded. Results: Although frequency of apnea after induction was higher and the duration of apnea was longer in group R, during procedure and postprocedure follow-up, there were no apnea episodes in either group (P < 0.05, P > 0.05). Intraoperative respiratory rate, time to eye opening, opioid consumption, and duration of recovery were significantly shorter in group R (P < 0.05). Conclusion: Remifentanil, when combined with propofol, can provide as efficient and safe anesthesia as fentanyl propofol combination for procedures like esophagogastroduodenoscopy. © TÜBİTAK.