High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with diabetic nephropathy and the role of netrin-1 levels

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Kor A., Baldane S., Ipekci S. H., Marakoglu K., Altinok A., Unlu A., ...More

Endocrine Abstracts, vol.1, no.1, pp.1-2, 2017 (Peer-Reviewed Journal)

  • Publication Type: Article / Abstract
  • Volume: 1 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1530/endoabs.49.gp96
  • Journal Name: Endocrine Abstracts
  • Page Numbers: pp.1-2
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


Background: Netrin-1 is an early biomarker of acute kidney injury. Besides, recent

studies have showed that netrin-1 promotes angiogenesis; but its usefulness for

peripheral artery disease (PAD) in type 2 diabetes patients is unknown.This study aimed

at investigating whether netrin-1 levelsare increased in peripheral artery disease among

patients with type 2 diabetes and also investigating possible associationsbetween

diabetic nephropathy (DN) and PAD.

Material and Methods: This was a cross-sectional observational clinical study. This study

involved a total of 84 adults with type 2 DM, who underwent ABI (low ankle-brachial

index) measurement in an outpatient clinic. PAD was de